ISSN: 2168-9296

Cell & Developmental Biology
Open Access

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David X. Liu
David X. Liu David X. Liu
Department of Neural and Behavioral Sciences
College of Medicine
Pennsylvania State University
USA
Research Interest

The focus of Dr. David Liu laboratory is to understand the signaling mechanisms that control death and viability of neurons and cancer cells. Our work has established that silencing of E2F responsive genes are required for neuron survival and that apoptotic stimulation leads to activation of cell cycle elements that promote E2F de-repression and neuron death. Our studies have further demonstrated that E2F-responsive apoptotic genes are silenced by E2F4-p130-Suv39H1-HDAC complexes in unstressed neurons and that apoptotic stimulation leads to CDK-dependent phosphorylation of p130, which results in disassembly of the E2F4-p130-Suv39H1-HDAC complexes on promoters of repressed apoptotic genes. Among these de-repressed apoptotic genes are transcription factors B- and C-myb. Elevation of B- and C-myb induces pro-apoptotic Bcl-2 family member Bim, provoking neuron death. One direction of our future work is to identify other key apoptotic genes that are controlled by the E2F de-repression pathway in neurons. Our lab uses interdisciplinary approaches including cellular, molecular, genetic, and biochemical techniques to dissect the apoptotic mechanisms used by neurons and cancer cells and to isolate novel proteins critical for regulation of cell death in those cells. We also use the same techniques to investigate how neural stem cells, such as telencephalic neuroprogenitor cells, are maintained and what promote their differentiation and survival.

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Publications

Cell Type-Dependent Function of Atf5: Where We Go from Here

Kathleen L. Lenge and David X. Liu

Editorial: Cell Dev Biol 2012, 1:e114
doi: 10.4172/2168-9296.1000e114
 
 
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