ISSN: 2165-7092

Pancreatic Disorders & Therapy
Open Access

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Fazlul H Sarkar
Fazlul H Sarkar

Fazlul H Sarkar
Professor
Departments of Pathology and Oncology
Wayne State University
USA

Biography

Dr. Sarkar is currently a Distinguished Professor, Departments of Pathology and Oncology at Karmanos Cancer Institute, Wayne State University School of Medicine. Dr. Sarkar’s early research, which still continues, is focused on understanding the role of a “master” transcription factor and the regulation of its upstream and downstream signaling molecules in solid tumors, and focusing on tumor microenvironment. Moreover, his research has been directed toward elucidating the molecular mechanism(s) of action of “natural agents”, their synthetic analogues, and other synthetic small molecule inhibitors of Bcl-2 and MDM2 for cancer prevention and therapy. The discoveries from in vitro and in vivo preclinical studies led to the design and execution of multiple Phase I/II clinical trials in breast, pancreas and prostate cancer for assessing the effects of several “natural agents” in the alterations of biomarkers as well as some early clinical efficacy testing. Dr. Sarkar’s research led to the concept of chemo-sensitization of cancer cells by reversing their drug-resistance phenotype to conventional therapeutics (chemo-radio-therapy), and all of which has been focused on tumor microenvironment, which led to clinical trials conducted at the Karmanos Cancer Institute. The innovation of his basic science research has attracted clinicians to collaborate with him, which clearly documents his leadership in translational research. Dr. Sarkar’s collaborations with basic scientists and physician scientists at MD Anderson Cancer Center led him to become a project leader for the Pancreas Cancer SPORE grant of MD Anderson Cancer Center under the leadership of Dr. James Abbruzzese, and Dr. Sarkar also served as a co-investigator for the University of Michigan Head and Neck Cancer SPORE grant.

Research Interest

Dr. Sarkar’s expertise in the field of cancer biology, cancer drug discovery, experimental therapeutics, medicinal chemistry, molecular mechanism of tumor aggressiveness with the tumor microenvironment, pre-clinical model research and conducting clinical trials. In addition, his experience is worth noticing in leading basic and clinical scientists to translate discoveries to early phase investigator-initiated clinical trials. Lastly, Dr. Sarkar’s activities clearly document his leadership expertise, and he really earned his well-deserved national and international stature in cancer research and drug discovery specifically focusing on conditioning the tumor microenvironment.

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Publications

Differential Expression of MicroRNAs in Tissues and Plasma Co-exists as a Biomarker for Pancreatic Cancer

Shadan Ali, Hala Dubaybo, Randall E Brand, Fazlul H Sarkar

Research Article: J Cancer Sci Ther/Vol.7.11 336-346 (2015)
doi: 10.4172/1948-5956.1000372
 
Identification of Differentially Expressed MiRNAs in Appendiceal Mucinous Cystadenocarcinoma from Mucinous Cystadenoma

Richard Licheng Wu, Shadan Ali, Fazlul H Sarkar, Rafic Beydoun

Research Article: J Cancer Sci Ther/Vol.7.11 328-335 (2015)
doi: 10.4172/1948-5956.1000371
 
Comparative Analysis of Differentially Expressed miRNAs and their Downstream mRNAs in Ovarian Cancer and its Associated Endometriosis

Richard Licheng Wu, Shadan Ali, Sudeshna Bandyopadhyay, Baraa Alosh, Kinda Hayek, MHD Fayez Daaboul, Ira Winer, Fazlul H Sarkar and Rouba Ali-Fehmi

Research Article: J Cancer Sci Ther/Vol.7.8 258-265 (2015)
doi: 10.4172/1948-5956.1000359
 
Notch Signaling Pathway in Pancreatic Cancer Progression

Jia Ma, Jun Xia, Lucio Miele, Fazlul H Sarkar and Zhiwei Wang

Review Article: Pancreat Disorders Ther 2013, 3: 114
doi: 10.4172/2165-7092.1000114
 
Systems and Network Pharmacology Approaches to Cancer Stem Cells Research and Therapy

Irfana Muqbil, Ginny W Bao, Rkya El-Kharraj, Minjel Shah, Ramzi M Mohammad, Fazlul H Sarkar and Asfar S Azmi

Review Article: J Stem Cell Res Ther 2012, S7-005
doi: 10.4172/2157-7633.S7-005
 
Identifying Biomarkers and Drug Targets Using Systems Biology Approaches for Pancreatic Cancer

Yi Tan, Lucio Miele, Fazlul H Sarkar and Zhiwei Wang

Editorial: Pancreat Disorders Ther 2012, 2:e128
doi: 10.4172/2165-7092.1000e128
 
Cancer Stem Cells: Coming of Age

Fazlul H Sarkar and Asfar S Azmi

Editorial: J Stem Cell Res Ther 2012, S7-e001
doi: 10.4172/2157-7633.S7-e001
 
The Role of Cancer Stem Cells and MicroRNAs in the Development and Progression of Pancreatic Cancer

Alia Ahmed, Shadan Ali, Philip A Philip and Fazlul H Sarkar

Review Article: J Stem Cell Res Ther 2012, S7-004
doi: 10.4172/2157-7633.S7-004
 
The Role of EMT in Pancreatic Cancer Progression

Qiong Wu, Lucio Miele, Fazlul H Sarkar and Zhiwei Wang

Editorial: Pancreat Disorders Ther 2012, 2:e121
doi: 10.4172/2165-7092.1000e121
 
Emerging Role of MicroRNA in Pancreatic Cancer

Jun Xia, Fazlul H Sarkar and Zhiwei Wang

Editorial: Pancreat Disorders Ther 2012, 2:e114
doi: 10.4172/2165-7092.1000e114
 

Pancreatic Disorders & Therapy - Cancer biology


 
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