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Biochemistry & Pharmacology: Open Access
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Leonard Amaral
Leonard Amaral Leonard Amaral
Institute of Hygiene & Tropical Medicine
Portugal
Read Interview session with Leonard Amaral
Biography

Leonard Amaral, M.D., PhD, Emeritus Professor, Universidade Nova de Lisboa and Distinguished Invited Scientist Fellow of the Fundacao de Ciencias e Tecnologia de Portugal.
Areas of current main contributions:
Development of therapy by which the resistance of MDR/XDR Mtb is by-passed and the non-killing macrophage is transformed into a killer of MDR/XDR Mtb.
Therapy of MDR/XDR TB with an inexpensive drug that is beyond patent protection, has no serious toxicity and has been now shown to cure XDR TB.
Development of new methods for the characterisation, evaluation and assessment of efflux pumps that render bacteria and cancer cells resistant to therapy.
Demonstration of biophysical/biochem mechanisms by which efflux pumps render bacteria multi-drug resistant.
Development of new theories for therapy of cancer based upon the 2nd law of thermodynamics.

Publication Record; over 200 scientific articles in Peer Review International Journals
Publications in Bacteriology, Immunology, Hematology, Clinical Pathology, Chemical Pathology, Endocrinology, Cancer, Human Embryology, Methods for Clinical Laboratories
Research Activity:
Development of drugs that are active (kill) against intracellular MDRTB and XDRTB.
Development of methods that assess and evaluate efflux pump activity of MDR bacteria.
Mechanisms by which efflux pumps are genetically controlled and regulated.
Development of agents that inhibit and or regulate efflux pumps.
Control of permeability of MDR bacteria to antibiotics.
Development of drugs that inhibit ABC transporters of mdr cancer cells.
Collaboration with 38 European Scientists from 33 countries via the Cost Action Programmes of the Eur Comm/Eur Sci FND-Cost Action B16 and BM0701 (ATENS).
Research supported by the Foundation of Science and Technology of Portugal
Workshops supported by the European Science Foundation
Interactive and cooperative projects supported by treaties between Portugal and participating EU countries
Leader in clinical trials for therapy of MDR/XDR TB infections.
 

Research Interest

Development of drugs that are active (kill) against intracellular MDRTB and XDRTB.
Development of methods that assess and evaluate efflux pump activity of MDR bacteria.
Mechanisms by which efflux pumps are genetically controlled and regulated.
Development of agents that inhibit and or regulate efflux pumps.
Control of permeability of MDR bacteria to antibiotics.
Development of drugs that inhibit ABC transporters of mdr cancer cells.
 

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Publications

Synergism between Antiplasmid Promethazine and Antibiotics In Vitro and InVivo

Joseph Molnár, Yvette Mándi, Gabriella Spengler, Leonard Amaral1,Ibolya Haszon, Sándor Turi and Miklós Kásler

Research Article: Mol Biol 2015, 4: 119
doi: 10.4172/2168-9547.1000119
 
Thioridazine: A Therapeutic Panacea for Efflux Pump Mediated Multidrug Bacterial Infections

Leonard Amaral

Commentary: J Biomol Res Ther 2015, 4: 123
doi: 10.4172/2167-7956.1000123
 
The World must Seriously Consider with Urgency the Use of Thioridazine in Combination with Conventional Antibiotics for Therapy of Extensively Drug Resistant Pulmonary Tuberculosis: Therapy Proven Effective in Argentina

Leonard Amaral

Editorial: Mycobact Dis 2014, 4: e130
doi: 10.4172/2161-1068.1000e130
 
Advances in Personalised Treatment of Multi-drug Resistant Tuberculosis

Leonard Amaral and Dick van Soolingen

Commentary: Biochem Pharmacol (Los Angel) 2014, 3: 148
doi: 10.4172/2167-0501.1000148
 
Synergism between Antiplasmid Promethazine and Antibiotics In Vitro and In Vivo

Joseph Molnár, Yvette Mándi, Gabriella Spengler, Ibolya Haszon, Sándor Turi, Miklós Kásler, and Leonard Amaral

Review Article: Biochem Pharmacol 2014, 3: 139
doi: 10.4172/2167-0501.1000139
 
Thioridazine as an Adjunct for Therapy of Multi-Drug (MDR), Extensively Drug Resistant (XDR) and Totally Drug Resistant (TDR) Pulmonary Tuberculosis Infections

Leonard Amaral

Editorial: Mycobact Dis 2013, 3: e120
doi: 10.4172/2161-1068.1000e120
 
The Role of Stroma in Tumour-Host Co-Existence: Some Perspectives in Stroma-Targeted Therapy of Cancer

Joseph Molnar,Ilona Mucsi, Helga Engi, Gabriela Spengler, Leonard Amaral, Attila Zalatnai, Qi Wang and Ben Efraim Shlomo

Research Article: Biochem & Pharmacol 2013, 2: 107
doi: 10.4172/2167-0501.1000107
 
A Cheap and Effective Anti-Mdr/Xdr/Tdr Tb Drug is Already Available

Leonard Amaral, Zarir F Udwadia and Dick van Soolingen

Editorial: Biochem & Pharmacol 2012, 1: e137
doi: 10.4172/2167-0501.1000e137
 
Sequential Responses of Bacteria to Noxious Agents (Antibiotics) Leading To Accumulation of Mutations and Permanent Resistance

Ana Martins, Gabriella Spengler, Joseph Molnar and Leonard Amaral

Research Article: Biochem & Pharmacol 2012, 1: 104
doi: 10.4172/2167-0501.1000104
 
Totally Drug Resistant Tuberculosis can be treated with thioridazine in combination with antibiotics to which the patient was initially resistant.

Leonard Amaral

Editorial: Biochem & Pharmacol 2012, 1: e102
doi: 10.4172/2167-0501.1000e102
 

Biochemistry & Pharmacology: Open Access - Efflux Pumps of Bacteria Energetics, Genetic Regulation; Methods for Physiological Assessment


Leonard Amaral, M.D., PhD, Emeritus Professor, Universidade Nova de Lisboa and Distinguished Invited Scientist Fellow of the Fundacao de Ciencias e Tecnologia de Portugal. Areas of current main contributions: Development of therapy by which the resistance of MDR/XDR Mtb is by-passed and the non-killing macrophage is transformed into a killer of MDR/XDR Mtb. Therapy of MDR/XDR TB with an inexpensive drug that is beyond patent protection, has no serious toxicity and has been now shown to cure XDR TB. Development of new methods for the characterisation, evaluation and assessment of efflux pumps that render bacteria and cancer cells resistant to therapy. Demonstration of biophysical/biochem mechanisms by which efflux pumps render bacteria multi-drug resistant. Development of new theories for therapy of cancer based upon the 2nd law of thermodynamics.

 
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