ISSN: 2165-7831
Journal of Blood & Lymph
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
 
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business
 

Hodgkin's Disease: Past to Present

Priyanka Pathak*
Physician, Kimmel Cancer Center, Department of Medical Oncology, Thomas Jefferson University, PA, USA
Corresponding Author : Priyanka Pathak, MD, MPH
Physician, Kimmel Cancer Center
Department of Medical Oncology
Thomas Jefferson University
111 S. 11th St, Philadelphia, PA 19107, USA
Tel: 281-536-9472
E-mail: Priyanka.pathak@jefferson.edu
Received March 28, 2015; Accepted March 30, 2015; Published April 10, 2015
Citation: Pathak P (2015) Hodgkin’s Disease: Past to Present. J Blood Lymph 5:e118. doi: 10.4172/2165-7831.1000e118
Copyright: © 2015 Pathak P, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Blood & Lymph

Editorial
Hodgkin’s disease (HD) is an uncommon malignancy accounting for an incidence of 0.6% of all cancers. In 2015, an estimated 9,050 people will be diagnosed with HD in the United States and 1,150 people will die from the disease [1]. From 2007 to 2011, the incidence rates for HD have been stable but death rates have been steadily decreasing by 2.2% per year for men and 2.7% for women per year for women. The latter have been attributed to better therapeutic interventions.
Once considered, the “inexorably fatal condition”, HD had long been a subject of controversy with respect to its nature, etiology and therapy. Initially thought to be an infectious disease due to its association with tuberculosis, definitive evidence of its neoplastic nature came in the 1960’s when cytogenetic studies confirmed its clonal derivation and aneuploidy.
The contiguous nature of its spread via lymphatic channels which was demonstrated when laparotomy was used as a staging tool at the Stanford University Medical Center for the first time in 1969, changed prevailing ideas of its treatment from essentially symptomatic to curative [2]. Treatment of HD has been fraught with controversy, ranging from surgical approaches which are no longer used, radiotherapy (extended field radiation versus involved field radiation) and chemotherapy (single versus multidrug regimens).
This disease has served as a model for the development of combined modality therapy with a multidisciplinary approach involving radiation oncologists, medical oncologists and radiologists. It has also served as the basis for interim PET/CT scans in the prognostication of other lymphomas and its treatment started the era of multi-agent chemotherapy for other hematologic malignancies.
HD has also been instrumental in the designing of long term studies which enables the assessment of the long-term effects of a treatment and helps us seek a balance between treatment effectiveness and the avoidance of long term gonadal, cardiac and secondary neoplastic complications.
Currently, the standard of care for previously untreated HD in the United States is combined modality therapy for Stage I and Stage II disease and combination chemotherapy (ABVD, Stanford V and BEACOPP) for advanced stages [3]. The 5 year survival rates for HD range from 90.8% for localized disease to 76.2% for distant disease [4]. Thus, we have come a long way from a potentially fatal disease to an imminently curable one.
In this issue, Salvatore et al. present a case of a 44 year old woman who presented with a bulky Stage II Hodgkin’s lymphoma with mediastinal syndrome. The patient had been aware of the tumor for about three years prior to her admission. This case report showcases a few important details- namely the natural history of Hodgkin’s disease which is rare with current medical advances, the effectiveness of current treatments and the social stigma of cancer which prevented her from seeking medical treatment leading to the fatal outcome.
References
Select your language of interest to view the total content in your interested language
 
Share This Article
   
 
   
 
Relevant Topics
Disc
Disc Acute Lymphoblastic Leukemia
Disc Acute Megakaryocytic Leukemia
Disc Acute Myelomonocytic Leukemia
Disc Acute Myleoid Leukemia
Disc Adenocarcinoma pancreas
Disc Advances in Alternative Lung Cancer Treatment
Disc Aleukemic Leukemia
Disc Anaemia Symptoms
Disc Anemia Causes
Disc Anti-Cancer Drug
Disc Anxiety Medicine
Disc Apoptosis
Disc Biology of Cancer
Disc Biomolecular Structure and Function
Disc Bipolar Medicine
Disc Bladder Carcinoma in Situ
Disc Blood
Disc Blood Cancer Symptoms
Disc Blood Clot in Brain
Disc Blood Clots
Disc Bone Cancer Stages
Disc Bone Marrow Cancer Survival
Disc Brain Tumor Treatment
Disc Breast Cancer Surgery
Disc Cancer Immunoediting
Disc Cancer Immunology
Disc Cancer Immunotherapies
Disc Cancer Radioimmunotherapy
Disc Cancer Science
Disc Cancer Therapies
Disc Cancer initiation and progression
Disc Carcinogenesis
Disc Cell Biology Junctions
Disc Cell Biology Techniques
Disc Cell Cycle
Disc Cell Death: Apoptosis
Disc Cell Regeneration
Disc Cell synthesis
Disc Cellular Biology
Disc Cellular DNA Studies
Disc Cellular Dynamics
Disc Cellular Immunotherapy
Disc Cellular Signalling
Disc Cellular and Molecular Biology
Disc Chemotherapies
Disc Chronic Lymphocytic Leukemia
Disc Chronic Myleloid Leukemia
Disc Colon Cancer Surgery
Disc DNA damage
Disc Depression Medicine
Disc Dermatologic Surgery
Disc Diabetic Medicine
Disc Ductal adenocarcinoma
Disc Esophageal Cancer
Disc Evolutionary Biology
Disc Factor XIII
Disc Feline Leukemia Complex
Disc Gene Expression and Regulation
Disc Haematologist
Disc Haemophilia
Disc Hairy Cell Leukemia
Disc Human Biology
Disc Immune Suppression
Disc Immunogene response
Disc Immunosurveillance
Disc Immunotherapeutic agents
Disc Immunotherapy or biologic therapy
Disc Iron Test
Disc Kidney Cancer Prognosis
Disc Kidney Cancer Surgery
Disc Large Cell Lymphoma
Disc Leukemia
Disc Leukemia Drugs
Disc Leukemia Surgery
Disc Leukemia Symptoms
Disc Lung Cancer Surgery
Disc Lung Tumor
Disc Lungs Cancer Cure
Disc Lymph Node Cancer
Disc Lymphoma Cancer
Disc Lymphoma Surgery
Disc Lymphoma Symptoms
Disc Lymphomatous polyposis
Disc Lymphosarcoma
Disc Mast Cell Leukemia
Disc Metastatic Cancer
Disc Methods and Techniques in Molecular Biology
Disc Molecular Biochemistry
Disc Molecular Biotechnology
Disc Molecular Cell
Disc Molecular Genetics
Disc Morbus Hodgkin
Disc Multiple Myeloma
Disc Mutagenesis
Disc Myeloma
Disc Necrosis
Disc Nucleic Acid Research
Disc Oesophageal Cancer Surgery
Disc Oseophagus Cancer
Disc Ovarian Cancer and Prognosis
Disc Pancreatic Cancer
Disc Pancreatic Cancer Surgery
Disc Pediatric Leukemia
Disc Photo carcinogenesis
Disc Plasma Cell Leukemia
Disc Prostate Cancer Surgery
Disc Radiation Therapy
Disc Sarcoma Cancer
Disc Sickle Cell Trait
Disc Skin Cancer Surgery
Disc Spleen Cancer
Disc Stem Cell Biology
Disc Stomach Cancer Surgery
Disc Systems of Immune
Disc T-cell Lymphomas
Disc Throat Cancer Surgery
Disc Thyroid Cancer Surgery
Disc Transitional cell carcinoma (TCC)
Disc Tumor Immunity
Disc Tumour Immunity
Disc Tumour Immunology
 
Recommended Journals
Disc Cancer Science
Disc Clinical Journals
Disc Pediatric Oncology Journal
Disc Mutagenesis Journal
Disc Carcinogenesis Journal
Disc Leukemia Journal
Disc Immunooncology Journal
Disc Cellular and Molecular Biology Journal
Disc Biology and Medicine Journal
Disc Cancer Surgery Journal
  View More»
 
Recommended Conferences
Disc 5th Hemophilia Congress
June 06-08 London, UK
Disc Leukemia and Bone Marrow Transplantation Conference
November 10-12, 2016 Istanbul, Turkey
 
Article Tools
Disc Export citation
Disc Share/Blog this article
 
Article usage
  Total views: 11166
  [From(publication date):
April-2015 - May 25, 2016]
  Breakdown by view type
  HTML page views : 7437
  PDF downloads :3729
 
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

 
OMICS International Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
 
 
OMICS International Conferences 2016-17
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings
 
 

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsinc.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsinc.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsinc.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsinc.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsinc.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsinc.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsinc.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsinc.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsinc.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsinc.com

1-702-714-7001Extn: 9039

Materials Science Journals

Rachle Green

materialsci@omicsinc.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsinc.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsinc.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsinc.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsinc.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsinc.com

1-702-714-7001 Extn: 9042

 
© 2008-2016 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version