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|Arun K. Rishi|
Arun K. Rishi
Department of Oncology and Internal Medicine
Wayne State University
Dr. Arun K. Rishi was born in Meerut, India. After the initial college education in India, Dr. Rishi obtained a M.Sc. in Biochemistry from University College London, UK, and a Ph.D. in Molecular Biology from Imperial College of Science Technology and Medicine, London, UK. He subsequently trained as a post-doctoral fellow at MIT and the Brigham and Womens Hospital, Harvard University Medical School, Boston, USA, and later held faculty positions at the Pulmonary Center, Boston University, Boston, and University of Maryland Cancer Center, Baltimore, Maryland, USA. Dr. Rishi is currently a professor at the Karmanos Cancer Institute and the Oncology Department of the Wayne State University School of Medicine, Detroit, Michigan, USA.
Dr. Rishi’s research interests focus on studying pathways and molecular mechanisms regulating cell growth/survival and death/apoptosis in cancer cells. Dr. Rishi identified and characterized a novel, apoptosis inducing protein termed CARP-1/CCAR1 that regulates apoptosis induced by diverse agents including an apoptogenic retinoid CD437, Adriamycin, Etoposide, but not by chemotherapy agents such as Cisplatin. CARP-1 also regulates apoptosis by EGFRs and protein kinase A. CARP-1 is a phospho-protein that functions in part by interacting with multiple regulators of cell growth and apoptosis signaling. Data from biopsies of human breast cancers and Non-Hodgkin’s Lymphomas (NHL) suggest an inverse correlation of CARP-1 expression with the grades of the tumors, indicating a potential prognostic value and a tumor suppressor property of CARP-1. Our on-going studies are focused to further elucidate the molecular mechanisms of adriamycin and EGFRs signaling that target CARP-1 and CARP-1 interactions with regulators of cell growth and apoptosis. Our long-term goal is to exploit this knowledge for development of strategies to inhibit a variety of cancers including the drug-resistant cancers.
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