alexa Georg F Weber | OMICS International | University of Cin
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Georg F Weber
Georg F Weber Georg F Weber
Associate Professor
College of Pharmacy
University of Cincinnati Academic Health Center

Georg F. Weber attended medical school in Wuerzburg, Germany. He worked at the Dana-Farber Cancer Institute, Harvard Medical School from 1990 through 1999 and is currently on the faculty at the University of Cincinnati. Georg F. Weber has published over 80 scientific reports, including many in the most respected professional journals, and various monographs, most recently a textbook on molecular oncology. He holds several patents. As a component of his mission to research cancer dissemination, Georg F. Weber is the founder and chief executive officer of MetaMolTheranostics, a company specialized in diagnosis and treatment of cancer metastasis.

Research Interest

Georg F. Weber has defined the genetic basis of metastasis formation as aberrant expression or splicing of a unique set of developmentally non-essential genes (stress response genes) that physiologically mediate the homing of immune system cells. Specifically, his laboratory has studied the cytokine osteopontin, which acts as a metastasis gene in multiple malignancies, including breast cancer. Based on the molecular mechanisms of osteopontin induction and function in cancer metastasis, he has established the following paradigms:
1. Osteopontin and variant CD44 interact, and this is essential for metastasis by several types of cancer.
2. Multiple osteopontin splice variants are present in malignant, but not in benign human breast tumor cells.
3. Metastasis genes support anchorage-independence in an autocrine fashion.
4. In cancer cells, distinct signal transduction pathways to growth and invasiveness are activated by oncogenes.
5. The expression (activation) of metastasis genes is triggered by cellular stress response programs and is regulated by multi-subunit transcription factor complexes. Georg F. Weber is the author of multiple monographs, most recently a textbook on molecular oncology.


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Enzyme Catalysis and the Outcome of Biochemical Reactions
Piotr Milanowski, Thomas J Carter and Georg F Weber
Research Article: J Proteomics Bioinform Vol.6.6 132-141 (2013)
DOI: 10.4172/jpb.1000271
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