alexa Hari Krishna Ananthula | OMICS International | Universi
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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Hari Krishna Ananthula
Hari Krishna Ananthula Hari Krishna Ananthula
The James L. Winkle College of Pharmacy
University of Cincinnati
USA

 
Biography

• Pharmacokinetic modeling experience using Phoenix® Winnonlin®, NLME™, NONMEM, R and Monolix. • PBPK Modeling experience using Simcyp® and GastroPlus™. • Application of allometric principles to predict in vivo pharmacokinetics in humans from pre-clinical data. • Cell Culture (Primary human hepatocytes, cryopreserved hepatocytes and tumor-derived cell lines). • In vitro cellular uptake studies and transport studies: designed and performed in vitro studies involving efflux transporters such as P-gp, BCRP, MRP and influx transporters such as OATP1B1 and PEPT. • Hands-on experience with in vitro drug-drug interaction methodologies including enzyme kinetics, inhibition, and induction using hepatocytes and microsomes. • Teaching experience as a Teaching Assistant to PharmD and Masters students in pharmacokinetics. • Bioanalysis: HPLC, LC-MS/MS and Liquid Scintillation Counter.

Research Interest

Pharmaceutical Sciences

 
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