alexa Acute Pancreatitis in Children– A Disorder against whose Incessant Attacks Even Hercules could not have Stood | Open Access Journals
ISSN: 2165-7548
Emergency Medicine: Open Access
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Acute Pancreatitis in Children– A Disorder against whose Incessant Attacks Even Hercules could not have Stood

Donna A Cheung and Edgardo D Rivera-Rivera*

Department of Paediatric Gastroenterology, University of Miami, Jackson Memorial Hospital, Miami, USA

*Corresponding Author:
Edgardo D Rivera-Rivera
Department of Paediatric Gastroenterology
University of Miami, Jackson Memorial Hospital
3005A 1601 NW 12th Ave, Miami, FL 33136, USA
Tel: 3052433166
E-mail: eriverarivera@med.miami.edu

Received Date: March 18, 2017; Accepted Date: March 25, 2017; Published Date: April 01, 2017

Citation: Cheung DA, Rivera-Rivera ED (2017) Acute Pancreatitis in Children– A Disorder against whose Incessant Attacks Even Hercules could not have Stood. Emerg Med (Los Angel) 7: 347. doi:10.4172/2165-7548.1000347

Copyright: © 2017 Rivera-Rivera ED, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited.

Visit for more related articles at Emergency Medicine: Open Access

Introduction

Acute pancreatitis is a reversible inflammatory process which results from auto-digestion of the pancreas from premature activation of pancreatic proenzymes [1]. Though reversible, this condition can lead to significant morbidity and mortality with up to a quarter of pediatric cases developing severe complications and mortality rates reaching up to 10% [2,3]. One of the proposed theories behind the death of Alexander the Great in 323 BC implicates acute pancreatitis [4]. The incidence of acute pancreatitis in children, like in adults, has been on the rise but acute pancreatitis has been clinically described since 1652. Dutch anatomist Tulp first described a young man with a suppurated pancreas on autopsy who presented with “continuous fever”, severe abdominal pain that “he had no possibility of lying down” and “was tortured to death by this agony in such a miserable way”, “against whose incessant attacks even Hercules could not have stood” [4-6]. This clinical scenario summarizes very well the presentation of acute pancreatitis. Clinical symptoms of acute pancreatitis include fever, nausea, vomiting, abdominal distension and constant epigastric abdominal pain aggravated by eating. In children, abdominal pain may be diffuse, back pain is less frequently involved and non-verbal children may present with irritability [7].

According to the 2012 consensus definition by the INSPPIRE consortium, the diagnosis of acute pancreatitis in children ≤ 18 years of age requires meeting two of three criteria (Table 1). Imaging features may include edema, necrosis, hemorrhage or abscess of the pancreas, peri-pancreatic inflammation or ascites. A pancreatic pseudocyst may also indicate a recent acute pancreatitis episode [7].

Diagnostic criteria for the diagnosis of pancreatitis in paediatrics
Abdominal pain compatible with acute pancreatitis
Serum pancreatic enzyme(s) (amylase and /or lipase) at least 3 times the upper limit of normal
Imaging findings (any study; can be US, CT or MRI) characteristic of, or compatible with acute pancreatitis

Table 1: Diagnostic criteria for the diagnosis of pancreatitis in paediatrics (from the INSPPIRE group recommendations).

Acute recurrent pancreatitis is a different entity that is diagnosed when two or more distinct episodes of acute pancreatitis occur with return to baseline in between. Acute recurrent pancreatitis and chronic pancreatitis are not covered in this review.

The main causes of acute pancreatitis in children are multiple (Table 2) [3,7]. The history should focus on discerning one of these possible etiologies when evaluating a patient with acute pancreatitis. It is particularly important in this age group to be mindful that trauma may be non-accidental. Laboratory evaluation may include the pancreatic enzymes, tests used as prognostic markers or tests used to identify possible etiologies. These may include calcium, triglycerides, transaminases, bilirubin, white blood cell count, urea nitrogen, and serum albumin [8,9]. Lipase is the more sensitive of the pancreatic enzymes in children. The daily monitoring of pancreatic enzymes is not routinely recommended, and management should be directed by the clinical status.

Common etiologies Less common etiologies
Biliary disease Metabolic disorders
Medication induced Familial
Infectious Hereditary
Trauma Autoimmune

Table 2: Etiologies for acute pancreatitis in paediatrics.

Various imaging modalities are available but the most commonly used is transabdominal ultrasonography as it is non-invasive, does not involve radiation exposure or sedation. It is not necessary for the diagnosis of pancreatitis, if the other two criteria are met, as ultrasonography of the pancreas will often be normal especially early in the disease process and in mild disease. The pancreas may also be difficult to examine on ultrasonography in acute pancreatitis because of overlapping bowel gas from a localized ileus or pain-induced aerophagia where patients swallow large quantities of air [3]. Ultrasonography is useful, however, to identify obstructive biliary disease such as gallstones and choledochal cysts. Other imaging modalities that may be utilized include CT with IV contrast, endoscopic retrograde cholangiopancreatography (ERCP), endoscopic ultrasonography (EUS), or magnetic resonance cholangiopancreatography (MRCP) with/without secretin stimulation.

Management of acute pancreatitis is predominantly derived from adult data and there are no established pediatric guidelines. Fluid resuscitation is the cornerstone to managing acute pancreatitis and is typically done with isotonic fluids. There is new adult data to suggest that Lactated ringers may potentially be better than normal saline [10]. Patients will generally require more than maintenance IV fluids but there are no recommendations on volume or rate in pediatric patients. Very young children may have difficulties maintaining their glucose levels with fasting and dextrose containing solutions (typically 5-10%) should be considered in their hydration management as well as glucose and electrolytes monitoring.

No preferred analgesic has been identified in clinical trials but opioids, including morphine, are considered appropriate options. Historically there is a concern that morphine may cause spasm of the sphincter of Oddi but there is limited data to support this [8,11,12]. With mild pancreatitis, oral low fat diet can be initiated quickly after improvement of pain regardless of pancreatic enzyme levels. Enteral nutrition has been shown to improve outcomes in severe pancreatitis. Enteral nutrition is believed to maintain mucosal integrity, inhibit bacterial translocation and lower morbidity. Total parenteral nutrition is reserved for cases unable to tolerate enteral nutrition. Studies have shown no difference between nasogastric and nasojejunal feeding [13,14]. Nasojejunal feeds requires specialty placement under radiological or endoscopic guidance and can be considered if nasogastric feeds are not tolerated. Polymeric or elemental formulas may be used. Antibiotic prophylaxis is not recommended and its use is reserved for treatment in necrotizing pancreatitis [15].

Acute pancreatitis can be a devastating disorder and more data is needed to establish appropriate guidelines and improve care in pediatric patients with acute pancreatitis. There is a lot of ongoing research and the INSPPIRE consortium was partly formed to tackle these gaps. Certainly, standardization of systems and the development and dissemination of scoring tools and management guidelines are very valuable in the process of improving patient’s care and outcomes [16]. This research is promising and will be able to help us better care for our young patients who have to battle a disorder whose “incessant attacks even Hercules could not have stood”.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 354
  • [From(publication date):
    April-2017 - Jul 26, 2017]
  • Breakdown by view type
  • HTML page views : 325
  • PDF downloads :29
 
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version