alexa Amar Bahadur Singh | OMICS International | Stanford Uni
ISSN: 2167-7956

Journal of Biomolecular Research & Therapeutics
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Amar Bahadur Singh

Amar Bahadur Singh Research Associate Office of Research & Development Stanford University Palo Alto, CA

Research Associate: Stanford Affiliated VA Palo Alto Health Care System, Palo Alto, California, (Research advisor: Dr. Jingwen Liu). My current focus research: Characterization of cellular genes that are regulated by diets, natural lipid lowering compounds, and cytokines in liver tissues, primary hepatocytes, and liver cell lines. Promoter analysis to identify critical cis-acting elements and trans-acting factors that play important roles in PPAR gene expression and regulation in liver cells. Regulation of LDLR mRNA levels and PPARs in hepatic lipid metabolism. 2012-2014 Postdoctoral Research: Division of Endocrinology, Gerontology & Metabolism, Stanford University, (Research advisor: Prof. Fredric B. Kraemer). Project was focus on regulation of LDLR mRNA by Berberine. we have generated a Luc-UTR in vivo model to study the regulation of LDLR mRNA stability in liver tissue of living mice, and by using this model we established inverse relationship between hnRNPD abundance and LDLR mRNA levels after BBR treatment of Alb-Luc-UTR mice Amar Bahadur Singh, Ph.D. suggests a critical function of hnRNPD in mediating hepatic LDLR mRNA degradation. We have also identified a novel posttranscriptional regulatory mechanism by which dietary cholesterol inhibits liver LDLR expression via inducing hnRNPD to accelerate LDLR mRNA degradation. 2009-2011 Postdoctoral Research: Molecular Cardiology, Cardiovascular Research Institute, Texas A&M Health Science Center, (Research advisor: Prof. Kenneth M. Baker). Project was focus on molecular mechanisms of RA-mediated signaling in hyperglycemia-induced cardiac remodeling, Using neonatal rat cardiomyocytes, we have demonstrated that hyperglycemia (HG)-induced oxidative stress and activation of the JNK pathway negatively regulated expression/activation of RAR and RXR. The impaired RAR/RXR signaling and oxidative stress/JNK pathway forms a vicious circle, which significantly contributes to hyperglycemia induced cardiomyocyte apoptosis. 2004-2009 Doctoral Research: Biochemistry Division, Central Drug Research Institute, Lucknow, (Research advisor: Dr. Arvind K Srivastava). My doctoral research was to focus on identification of new anti-diabetic and anti-dyslipidemic lead molecules from different source of compounds & exploration of their mechanism of action (s). I was also working on nuclear receptors that are mainly involved in regulation of glucose, cholesterol and lipid metabolism like PPAR, RAR, RXR, LXR and FXR. Simultaneously, I was also screened the new agonists /antagonist ligand molecules from different series of compounds synthesized by medicinal chemistry division of our Institute and are exploring the relevance of these ligands for therapeutics in pathophysiological conditions such as diabetes, dyslipidemia and atherosclerosis. PROFESSIONAL MEMBERSHIP 2010-Present American Heart Association.

Research Interest

New drug discovery R&D on diabetes, Obesity, Hyperlipidemia, Cardiovascular diseases.

OMICS International Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
OMICS International Conferences 2016-17
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Materials Science Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2016 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version