ISSN: 2169-0111

Advancements in Genetic Engineering
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Arvind Chhabra
Arvind Chhabra Executive Editor
Arvind Chhabra

Department Of Medicine
University of Connecticut Health Center
USA
Tel. 860-679-1447
Biography

Arvind Chhabra is an Assistant Professor at Department of Medicine and Stem Cell Institute of University of Connecticut Health Center. He has completed his postdoctoral research in 2007 from Department of Medicine, University of Connecticut Health Center before which he attained his doctoral degree from Department of Microbiology of Central Drug Research Institute (CDRI) located at Lucknow, India in 2001.

Research Interest

His research work is aimed at developing an effective immune based cancer therapy. Since most human tumor antigens identified are "self-antigens", and most human tumors are MHC class I positive, but MHC class II negative, the generation of a potent anti-tumor immune response faces many inherent constraints. Among these include, an extremely low precursor frequency of antitumor T cells in most cancer patients, and the lack of an effective method to engage CD4 T cells in tumor immunity, especially in an antigen specific manner. They have developed multiple approach to effectively address these limitation, utilizing the human melanoma associated antigens as model tumor antigens. He have published his findings in prominent peer-review journals and research work has earned him several awards at international cancer immunotherapy meetings. In addition to his work on human melanoma, ongoing research efforts in his laboratory are aimed at extending his expertise to the human breast cancer model and also to utilize the human pluripotent stem cells [hPS, i.e. human embryonic stem cells (hES) and induced pluripotent stem cells (iPS)] for developing patient specific cancer immunotherapy approaches through TCR engineering approach.

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Publications

Transcriptional Profiles of Mart-1(27-35) Epitope Specific TCReng Human CD8+ and CD4+ T Cells upon Epitope Encounter as Elucidated by RNASeq

Prashant Singh, Nitya G Chakraborty, Sidharth S Jha, Umar Farooq, Mei Xiao, Veneta Qendro, Arvind Chhabra, Richard Everson, David I Dorsky, Upendra P Hegde and Bijay Mukherji

Research Article: Immunome Res 2015, S2: 004
doi: 10.4172/1745-7580.S2.004
 
Cancer Immunotherapy: Targeting Checkpoint Blockade

Arvind Chhabra

Review Article: Adv Genet Eng 2015, 4:118
doi: 10.4172/2169-0111.1000118
 
Advances in Genome Engineering Approaches

Arvind Chhabra

Editorial: Adv Genet Eng 2014, 3: e107
doi: 10.4172/2169-0111.1000e107
 
Engineering Anti-Tumor T Cell Immunity

Arvind Chhabra

Commentary: Adv Genet Eng 2013, 2: 104
doi: 10.4172/2169-0111.1000104
 
 
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