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ISSN: 2169-0111

Advancements in Genetic Engineering

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Editor-in-Chief

Editor in Chief Editor-in-Chief
Ming Pei

Associate Professor
Department of Orthopaedics
West Virginia University, USA
Tel. 304-293-1072
Fax: 304-293-7070

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Submit manuscript at http://www.editorialmanager.com/biobiogroup/default.aspx or send as an e-mail attachment to the Editorial Office at editor.age@omicsonline.org
 

About the Journal

Impact Factor: 1.00 *

NLM ID:101600827
ISSN: 2169-0111

Genetic Engineering is a technique of controlled manipulation of genes to change the genetic makeup of cells and move genes across species boundaries to produce novel organisms. Advancements in Genetic Engineering journal provide an opportunity to share the information on Genetic engineering techniques and its application to numerous fields of research, biotechnology, and medicine among scientists and researchers.

The journal includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises a peer review process for the submitted manuscripts for the quality of publishing. Advancements in Genetic Engineering focused on the areas such as Mutant organisms, DNA Replication, Recombinant DNA, Genetic linkage analysis, Genetically Modified Plants, Genetically Modified Animals, DNA Microarray, Green Fluorescent Protein, Protein Sequencing, Genetic Probes, RNA Splicing, Functional Genomics, Antisense RNA, RFLP, Biosafety of GMO, GMO Ethics , Genetically Engineered Microorganism, Computational genomics Advancements in Genetic Engineering is an Open Access journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide.

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http://www.editorialmanager.com/biobiogroup/ or send as an e-mail attachment to the Editorial Office at editor.age@omicsonline.org or editor.age@omicsinc.com

Human genetic engineering

Human Genetic engineering is the deliberate, controlled manipulation of the genes in an organism with the intent of making that organism better in some way. This is usually done independently of the natural reproductive process.

Genetically engineering foods

Genetic engineering modifies the DNA of crops to display specific traits, such as a resistance to pesticides and herbicides. Genetically engineered (GE) crops are often also referred to as genetically modified organisms (GMOs) or biotech crops. In recent years, the Food and Drug Administration began paving the way for approval of GM animals, such as salmon. The first genetically modified animal approved for human consumption, supporters of GM salmon claim it grows at twice the normal rate.

Genetically engineered animals

A genetically engineered organism, also known as a transgenic organism, is any organism whose genetic material has been altered using genetic engineering techniques. GEOs are the source of genetically modified foods and are also widely used in scientific research and to produce goods other than food. The term GEO is very close to the technical legal term, 'living modified organism', defined in the Cartagena Protocol on Biosafety, which regulates international trade in living GEOs (specifically, "any living organism that possesses a novel combination of genetic material obtained through the use of modern biotechnology").

Genetic linkage analysis

Genetic linkage analysis is a statistical method that is used to associate functionality of genes to their location on chromosomes. Neighboring genes on the chromosome have a tendency to stick together when passed on to offsprings. Therefore, if some disease is often passed to offsprings along with specific marker-genes , then it can be concluded that the gene(s) which are responsible for the disease are located close on the chromosome to these markers.

Genetic Probes

Genetic Probes is a fragment of DNA or RNA of variable length (usually 100-1000 bases long) which is radioactively labelled used in DNA or RNA samples to detect the presence of nucleotide sequences (the DNA target) that are complementary to the sequence in the probe. The probe thereby hybridizes to single-stranded nucleic acid (DNA or RNA) whose base sequence allows probe-target base pairing due to complementarity between the probe and target.

Protein Sequencing

Protein sequencing is a technique to determine the amino acid sequence of a protein, as well as which conformation the protein adopts and the extent to which it is complexed with any non-peptide molecules. Discovering the structures and functions of proteins in living organisms is an important tool for understanding cellular processes, and allows drugs that target specific metabolic pathways to be invented more easily.

Gene cloning

Gene cloning is the process in which a gene of interest is located and copied (cloned) out of DNA extracted from an organism? When DNA is extracted from an organism, all of its genes are extracted at one time. This DNA, which contains thousands of different genes.

Genetic linkage analysis

Genetic linkage analysis is a statistical method that is used to associate functionality of genes to their location on chromosomes. Neighbouring genes on the chromosome have a tendency to stick together when passed on to offspring’s.

Protein Sequencing

Protein sequencing is a technique to determine the amino acid sequence of a protein, as well as which conformation the protein adopts and the extent to which it is complexed with any non-peptide molecules. Discovering the structures and functions of proteins in living organisms is an important tool for understanding cellular processes, and allows drugs that target specific metabolic pathways to be invented more easily.

RFLP

RFLP (often pronounced "rif lip", as if it were a word) is a method used by molecular biologists to follow a particular sequence of DNA as it is passed on to other cells. RFLPs can be used in many different settings to accomplish different objectives.

Trans-Genesis

Transgenes is the process of introducing an exogenous gene — called a transgene — into a living organism so that the organism will exhibit a new property and transmit that property to its offspring. Transgenes can be facilitated by liposomes, plasmid vectors, viral vectors, pronuclear injection, protoplast fusion, and ballistic DNA injection.

Insulin genetics

The Insulin genetics provides instructions for producing the hormone insulin, which is necessary for the control of glucose levels in the blood. Glucose is a simple sugar and the primary energy source for most cells in the body.

DNA Replication

DNA replication is the process of producing two identical replicas from one original DNA molecule. This biological process occurs in all living organisms and is the basis for biological inheritance.

Genetic engineering application

Genetic engineering, also called genetic modification, is the direct manipulation of an organism's genome using biotechnology. New DNA may be inserted in the host genome by first isolating and copying the genetic material of interest using molecular cloning methods to generate a DNA sequence, or by synthesizing the DNA, and then inserting this construct into the host organism. Genes may be removed, or "knocked out", using a nuclease. Gene targeting is a different technique that uses homologous recombination to change an endogenous gene, and can be used to delete a gene, remove exons, add a gene, or introduce point mutations.

Ethics in genetic engineering

Ethical issues, including concerns for animal welfare, can arise at all stages in the generation and life span of an individual genetically engineered animal. The following sections detail some of the issues that have arisen during the peer-driven guidelines development process and associated impact analysis consultations carried out by the CCAC. The CCAC works to an accepted ethic of animal use in science. However, despite the steps taken to minimize pain and distress, there is evidence of public concerns that go beyond the Three Rs and animal welfare regarding the creation and use of genetically engineered animals.

Recombinant DNA

Recombinant DNA (rDNA) molecules are DNAmolecules formed by laboratory methods of genetic recombination (such as molecular cloning) to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in biological organisms.

RNA Splicing

In molecular biology and genetics, splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined. For nuclear encoded genes, splicing takes place within the nucleus after or concurrently with transcription.

Green genetic engineering

Green genetic engineering as it is used in agriculture and the food industry is all about creating new species of plants that are highly resistant to pests and pesticides or contain higher levels of nutrients than traditional plants. The idea is not new; in fact, farmers have been doing this for thousands of years, crossing and breeding plants to produce new and stronger species.

Genetic engineering crops

Genetically engineering crops, biotech crops are plants used in agriculture, the DNA of which has been modified using genetic engineering techniques. In most cases the aim is to introduce a new trait to the plant which does not occur naturally in the species. Examples in food crops include resistance to certain pests, diseases, or environmental conditions, reduction of spoilage, or resistance to chemical treatments (e.g. resistance to a herbicide), or improving the nutrient profile of the crop. Examples in non-food crops include production of pharmaceutical agents, biofuels, and other industrially useful goods, as well as for bioremediation.

Molecular Cloning

Molecular cloning is a set of experimental methods in molecular biology that are used to assemble recombinant DNA molecules and to direct their replication within host organisms.

Functional Genomics

Functional genomics is a field of molecular biology that attempts to make use of the vast wealth of data produced by genomic and transcriptomic projects (such as genome sequencing projects and RNA-seq) to describe gene (and protein) functions and interactions.

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Advancement in Genetic Engineering is associated with  “4th International conference on Clinical Microbiology & Microbial Genomics” (Clinical Microbiology-2015) during October 05-07, 2015 at Philadelphia, USA. with a theme "Analyzing The Innovation & Future Trends In Clinical Microbiology ". We are particularly interested in Genetics research in the areas of genomics, Mutant organisms, DNA Replication, Recombinant DNA, Genetic linkage analysis, Genetically Modified Plants, Genetically Modified Animals, DNA Microarray, Green Fluorescent Protein, Protein Sequencing, and Genetic Probes. We encourage articles involving genome-wide DNA methylation mapping and gene expression including histone replacement, messenger RNA interference (miRNA) as well any other epigenetic studies.

 

 

*Unofficial 2014 Impact Factor was established by dividing the number of articles published in 2012 and 2013 with the number of times they are cited in 2014 based on Google search and the Scholar Citation Index database. If 'X' is the total number of articles published in 2012 and 2013, and 'Y' is the number of times these articles were cited in indexed journals during 2014 than, impact factor = Y/X

 

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