Journal of Single Cell Biology focuses on new technologies and their applications in medical and biological analyses at single-cell resolution and often at a genome-wide scale enabling a new understanding of complex biological phenomena. Single-cell biology is a new field combining multiple disciplines. The technologies developed in genomics, transcriptomics, epigenomics, proteomics, metabolomics and other fields are often used in this new discipline. Some tools in traditional physics, chemistry and novel methods in mathematics are also contributing to the ability to study biology at the single-cell level.
Single Cell Biology focused on areas like Cell Metabolism, Cell signaling, Cell Physiology, Stem Cell Niche, Stem Cell , Cancer Cell biology, Protein Fuction, Structural biology, Cell Movement, Cell Senescence, Immunohistochemistry, Cell fractionation, Immunoprecipitation, Cellular microbiology, Cellular compartments etc.
Single Cell Biology is a peer reviewed scientific journal known for rapid dissemination of high-quality research. This Single Cell Biology Journal with high impact factor offers an open access platform to the authors in academia and industry to publish their novel research. It serves the International Scientific Community with its standard research publications. This is a journal by the community and for the community. We encourage experts from biology and medicine to work with us to achieve our goal. The journal will emphasize high-level research of single-cell biology in terms of technology, academic and clinical applications (especially in vitro diagnosis), data analysis, algorithm and theory and beyond. We will work hard to maintain a high quality journal that is innovative and helpful to researchers in biological and medical science.
We wish to encourage more contributions from basic research, biomedical, industrial and clinical laboratories to ensure continued success of the journal. We invite the submission of original research, reviews of the literature, short communications, commentaries, case reports, book reviews, and works-in-progress. Editors, reviewers, authors and readers are the foundation of this journal, and I am obligated to use their valuable contributions to take the journal to greater heights. We are delighted that you are joining us as readers and hope you will also join us as contributors. Any comments or suggestions you may have that would improve this journal are welcome.
The journal is using Editorial Manager System for quality in review process. Editorial Manager is an online manuscript submission, review and tracking systems. Review process is performed by the editorial board members of Single Cell Biology or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript. Authors may submit manuscripts and track their progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process.
Single cells are also known as unicellular organisms. Single cell organisms are microscopic and composed of a single cell, unlike multicellular organisms that are made of many cells. They can live and carry out all of their life processes as one single cell. Unicellular organisms are divided into two categories: Eukaryotic and Prokaryotic Organisms. Some of the examples of single cell organisms are prokaryotes, most protists, and some fungi.Individual cells can differ dramatically in size, protein levels, and expressed RNA transcripts, and these variations are key to answering previously irresolvable questions in cancer research, stem cell biology, immunology, developmental biology, and neurology.The measurement of specific proteins and transcripts in individual cells is critical for understanding the role of cellular diversity in development, health, and disease.
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Single Cell Biology, Journal of Clinical & Cellular Immunology, Journal of Stem Cell Research & Therapy, Cellular and Molecular Biology, Journal of Cell Science & Therapy, Cell & Developmental Biology, Advances in Anatomy Embryology and Cell Biology, Cell Biology and Toxicology, Cell Biology International, Current Opinion in Cell Biology, Immunology and Cell Biology, Journal of Cell Biology, Membrane and Cell Biology, Methods in Cell Biology
Single Cell Imaging is a microscopy technique that will collect data from separate individual cells, as opposed to values averaged over population of cells. It reveals populations of genetically identical calls which often present heterogeneous phenotypes and it often relies on fluorescent molecules. It is used by scientists to obtain a better understanding of biological function through the study of cellular dynamics. Recent progress in this field has led to the development of a number of genetically encoded fluorescent biosensors, which upon recombinant expression are able selectively to detect real-time changes in IP(3) in single live cells.Live-cell imaging and computational modelling are compatible techniques which allow quantitative analysis of cell signalling pathway dynamics. Non-invasive imaging techniques, based on the use of various luciferases and fluorescent proteins, trace cellular events such as gene expression, protein-protein interactions and protein localization in cells. By employing a number of markers in a single assay, multiple parameters can be measured simultaneously in the same cell.
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Journal of Cell Signaling, Journal of Cellular & Molecular Pathology, Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology, Insights in Cell Science, Insights in Stem Cells, Cellular Signalling, Protein & cell, Cell, Molecular Cell, Developmental Cell, Cell Stem Cell, Cell Cycle
Gene Expression in individual cells varies from tissue or culture sample according to Cell cycle, genetic, epigenetic and stochastic differences. Single Cell Differentiation is neglected in in the analysis of the functional consequences of genetic variation. The expression of 92 genes affected by signaling in 1,440 single cells from 15 individuals is measured individuals to associate single-nucleotide polymorphisms (SNPs) with gene-expression phenotypes, while accounting for stochastic and cell-cycle differences between cells.Complex tissues may contain very small cell subpopulations with unique gene expression profiles, and averaging gene expression results from many cells can mask subtle, important changes occurring within single cells. Technical advances in single cell isolation, such as laser capture microdissection and fluorescence-based cell sorting, provide the means to capture and recover individual cells, but the detection of minute starting amounts of RNA remains a significant challenge to studying gene expression in these tiny samples, particularly when analysis of multiple targets is required.
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Journal of Molecular and Genetic Medicine, Journal of Phylogenetics & Evolutionary Biology, Immunogenetics: Open Access, Advancements in Genetic Engineering, Critical Reviews in Eukaryotic Gene Expression, Gene Expression Patterns, Gene Expression, Genes to Cells, Cell Stem Cell
Single cell genome is of great interest to researchers. Probing the genetic make –up of individual cells would understand a wide range of organisms that cannot be grown in lab from bacteria that lives in digestive tracts and on our skin. Single-cell genetic studies are also being used to study stem cells, cancer cells and the human brain, which is made up of cells that increasingly appear to have significant genomic diversity.Advances in whole-genome and whole-transcriptome amplification have permitted the sequencing of the minute amounts of DNA and RNA present in a single cell, offering a window into the extent and nature of genomic and transcriptomic heterogeneity which occurs in both normal development and disease. Single-cell approaches stand poised to revolutionise our capacity to understand the scale of genomic, epigenomic, and transcriptomic diversity that occurs during the lifetime of an individual organism.
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Single Cell Biology, Journal of Molecular and Genetic Medicine, Journal of Phylogenetics & Evolutionary Biology, Immunogenetics: Open Access, Advancements in Genetic Engineering, Genome Research, Genome Biology, Cytogenetic and Genome Research, Genome Biology and Evolution, Advances in Genome Biology, Genome Integrity, Genome Dynamics and Stability
Single Cell Analysis refers to the study of individual cells isolated from tissues in multi-cellular organisms. Study of living cells can increase the understanding of the interconnecting molecular events continually taking place in each cell. The Single Cell Analysis examinines the transcriptional signatures of individual human cells in order to measure and analyze cellular heterogeneity and to define specific cell types and/or cell “states”. Single cell analysis can enable you to unlock the mystery in gene expression profiles between individual cells. Single-cell analysis is crucial for elucidating cellular diversity and heterogeneity, not only in tissue specimens but also in “liquid biopsy” specimens, such as circulating tumor cells (CTCs) and peripheral mononuclear blood specimens (PBMCs)
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Journal of Clinical & Cellular Immunology, Journal of Stem Cell Research & Therapy, Cellular and Molecular Biology, Journal of Cell Science & Therapy, Cell & Developmental Biology, Journal of Cellular and Molecular Medicine, Seminars in Cell and Developmental Biology, Cell and Tissue Research, Cell Research, Molecular and Cellular Neurosciences, Experimental Cell Research
Single Cell proteins are dried cells of microorganisms or extracted from pure or mixed cultures of algae, yeasts, fungi or bacteria. They can use as feed supplement and protein supplement for humans. Earlier it was known as Microbial Protein. Pruteen was first commercial SCP used as an animal feed additive. Biomass plays an important role in production of SCP. Single cell proteins have application in animal nutrition as: fattening calves, poultry, pigs and fish breading. In food it is used as : aroma carriers, vitamin carrier, emulsifying aids and to improve the nutritive value of baked products, in soups, in ready-to-serve-meals, in diet recipes and in the technical field in : paper processing, leather processing and as foam stabilizers
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Journal of Cell Signaling, Journal of Cellular & Molecular Pathology, Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology, Insights in Cell Science, Insights in Stem Cells, Protein Science, Protein and Cell, Membrane Protein Transport, Protein Journal, International Journal of Peptide and Protein Research, Advances in Protein Chemistry and Structural Biology
DNA Barcoding is a taxonomic method which uses a short genetic marker in an organism’s DNA to identify its belonging to a particular species. Barcodes are also used to identify unknown species. The most commonly used barcode region for animals is segment of 600 base pairs of mitochondrial gene cytochrome Oxidase I.DNA barcoding first came to the attention of the scientific community in 2003 when Paul Hebert’s research group at the University of Guelph published a paper titled "Biological identifications through DNA barcodes". In it, they proposed a new system of species identification and discovery using a short section of DNA from a standardized region of the genome.Species identification using DNA barcodes starts with the specimen. Barcoding projects obtain specimens from a variety of sources. Some are collected in the field, others come from the vast collections housed in natural history museums, zoos, botanical gardens and seed banks to name a few.
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Journal of Genetic Syndromes & Gene Therapy, Hereditary Genetics: Current Research, Human Genetics & Embryology, Journal of Molecular and Genetic Medicine, Journal of Cell Science & Therapy, DNA Research, DNA and Cell Biology, Advances in DNA Sequence-Specific Agents, Recent Patents on DNA and Gene Sequences, Mutation Research - DNA Repair
A single cell is the building block for human life. Cell culture involves the dispersal of cells in an artificial environment composed of nutrient solutions, a suitable surface to support the growth of cells, and ideal conditions of temperature, humidity, and gaseous atmosphere. The major advantage of cell culture is the consistency and reproducibility of results that can be obtained from using a batch of clonal cells.Cell culture is one of the major tools used in cellular and molecular biology, providing excellent model systems for studying the normal physiology and biochemistry of cells, the effects of drugs and toxic compounds on the cells, and mutagenesis and carcinogenesis. It is also used in drug screening and development, and large scale manufacturing of biological compounds. The major advantage of using cell culture for any of these applications is the consistency and reproducibility of results that can be obtained from using a batch of clonal cells.
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Cell motility is needed for some vital physiological procedures amid improvement, for example, cell movement amid gastrulation, axon direction, tissue recovery and embryological advancement. A type of cell motility includes the dynamic transport of membranous organelles inside of the cytoplasm. This type of development is needed for fitting association of the cytoplasmic substance, and the redistribution of metabolites, hormones, and different materials inside of the cell. Cell motility is one of the crowning achievements of evolution. Primitive cells were probably immobile, carried by currents in the primordial milieu. With the evolution of multicellular organisms, primitive organs were formed by migrations of single cells and groups of cells from distant parts of the embryo. Cell motility is required for many important physiological processes during development, such as cell migration during gastrulation, axon guidance, tissue regeneration and embryological development.
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The cytoskeleton is a series of intercellular proteins that help a cell with shape, support, and movement. It is a dynamic three-dimensional structure that fills the cytoplasm. The primary types of fibers comprising the cytoskeleton are microfilaments, microtubules, and intermediate filaments. This structure acts as both muscle and skeleton, for movement and stability. A cytoskeleton can position cell structures in specific places within the cell, or it can move cell structures from one end of the cell to the other. Microtubules function to support the cell shape, but they also help cell division. The intermediate filaments are called intermediate because they are the mid-sized fibers of the cytoskeleton, measuring 8-12 nanometers in diameter.
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A membrane-bound intracellular vacuole that contains fragments of partially digested cell components; indigestible debris persists as lipofuscin. Autophagosome formation depends on the activity of a type III PI3K lipid kinase. Autophagosomes convey cytoplasmic parts to the lysosomes. The outer membrane of an autophagosome fuses with a lysosome to form an autolysosome. The lysosome's hydrolases degrades the autophagosome-conveyed substance and its internal membrane. Autophagy is a tightly regulated intracellular bulk degradation/recycling system that has fundamental roles in cellular homeostasis. Autophagy is initiated by isolation membranes, which form and elongate as they engulf portions of the cytoplasm and organelles. The different steps of autophagy, from the signal transduction events that regulate it to the completion of this pathway by fusion with the lysosome/vacuole.
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Membrane trafficking is the process by which proteins and other macromolecules are distributed throughout the cell, and released to or internalized from the extracellular space. Membrane trafficking is essential for transport of proteins and other macromolecules to various destinations inside and outside of the cell. Membrane trafficking also helps cells to maintain cellular homeostasis, as well as to meet specific demands during signal perception and transduction. Trafficking within the network supports intercellular communication and construction of extracellular matrix through secretion, nutrient import and processing of extracellular signals through endocytosis, and periodic turnover and renewal of cellular organelles. Unfortunately, membrane trafficking also facilitates invasion of cells by pathogenic microorganisms, and trafficking defects occur in several diseases. Thus the mechanisms of membrane trafficking are central to both cellular physiology and pathology. Research in the Department of Cell Biology addresses both the physiological and pathological aspects of membrane trafficking.
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Centriole is a cylindrical cell structure composed mainly of a protein called tubulin that is found in most eukaryotic cells. The centrioles play a major role in cell division. Centrioles replicate during the interphase stage of mitosis and meiosis. Centrioles called basal bodies form cilia and flagella. Most centrioles are made up of nine sets of microtubule triplets, arranged in a cylinder. Centrioles are present in animal cells and the basal region of cilia and flagella in animals and lower plants. In cilia and flagella centrioles are called ‘basal bodies’ but the two can be considered inter-convertible.Centrioles are absent from the cells of higher plants. Centrioles function as a pair in most cells in animals but as a single centriole or basal body in cilia and flagella. In animal cells centrioles organise the pericentriolar material to produce microtubules including mitotic spindle fibres.
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Transcription is the process by which the information in DNA is copied into messenger RNA (mRNA) for protein production by the enzyme RNA polymerase. It is the first step of gene expression. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, antiparallel RNA strand called a primary transcript. Although transcription is performed by RNA Polymerase, the enzyme needs other proteins to produce the transcript. These factors are either associated directly with RNA Polymerase or add in building the actual transcription apparatus. The general term for these associated proteins is transcription factor. Transcription factor is any protein other than RNA Polymerase that is required for transcription.
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Polymerization is a process in which small molecules, called monomers, combine chemically to produce a very large chainlike or network molecule, called a polymer. At least 100 monomer molecules must be combined to make a product that has certain unique physical properties. The formation of stable covalent chemical bonds between the monomers sets polymerization apart from other processes, such as crystallization. Usually at least 100 monomer molecules must be combined to make a product that has certain unique physical properties—such as elasticity, high tensile strength, or the ability to form fibres—that differentiate polymers from substances composed of smaller and simpler molecules; often, many thousands of monomer units are incorporated in a single molecule of a polymer.
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The simplest processes for monitoring cell movement and location use tracking probes that pass through the membrane into the cell and become membrane-impermeant after loading. Long-term tracking of cell movement and location requires probes that are more resistant to photobleaching and are retained through more cycles of cell division. The visualization of cellular behaviors such as division, movement, and apoptosis at a single-cell resolution and, in principle, allows the prospective and retrospective tracking towards determining the lineage of each cell. The generation of genetically encoded fluorescent protein reporters that are fused with subcellularly localized proteins, such as human histone H2B, has made it possible to direct fluorescent protein reporters to specific subcellular structures and identify single cells in complex populations.
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Journal of Single Cell Biology is associated with our International Conference “5th International Conference and Exhibition on Cell and Gene Therapy” during May 19-21, 2016 San Antonio, USA with a theme "Frontiers in Cell and Gene Therapy: From Bench to Bedside". We are particularly interested in research in the areas of Gene Therapy,Cell and Gene Therapy Products, Cellular Therapy, Stem Cell Products, Clinical Trials in Cell & Gene Therapy, Molecular Epigenetics. We encourage articles involving single cells, fluidism single cell, single cell imaging, single cell gene expression, single cell genome, single cell analysis.
*Unofficial 2015 Journal Impact Factor was established by dividing the number of articles published in 2013 and 2014 with the number of times they are cited in 2015 based on Google search and the Scholar Citation Index database. If 'X' is the total number of articles published in 2013 and 2014, and 'Y' is the number of times these articles were cited in indexed journals during 2015 then, impact factor = Y/X