alexa All Roads Lead to Rome? Distinct Neural Circuits in Different Developmental Disorders are Related to Reading Difficulties in Children | Open Access Journals
ISSN: 2168-975X
Brain Disorders & Therapy
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

All Roads Lead to Rome? Distinct Neural Circuits in Different Developmental Disorders are Related to Reading Difficulties in Children

Tzipi Horowitz-Kraus*
Career Advanced Chair, The Neurocognitive Center for Language, Reading, and Literacy, Faculty of Education in Science and Technology, Technion- Israel Institute of Technology Haifa, Israel
General and Community Pediatrics, Reading and Literacy Discovery Center, Cincinnati Children’s Hospital Medical Center, Ohio, USA
Corresponding Author : Tzipi Horowitz-Kraus
The Neurocognitive Center for Language
Reading, and Literacy, Faculty of Education in Science and Technology
Technion- Israel Institute of Technology Haifa, Israel
E-mail: Tzipi.Horowitz-
Received:November 22, 2015;Accepted: December 01, 2015; Published:December 09, 2015
Citation: Horowitz-Kraus T (2015) All Roads Lead to Rome? Distinct Neural Circuits in Different Developmental Disorders are Related to Reading Difficulties in Children. Brain Disord Ther 4:197. doi:10.4172/2168-975X.1000197
Copyright: ©2015 Horowitz-Kraus T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Brain Disorders & Therapy

Reading is defined as the ability to extract semantically meaningful, verbal information from written language. This is one of the most important cognitive academic abilities and has been found to be related to scores on the American College Test [1]. However, reading is not as intuitive as we may think. The neuroimaging era provides insights into the neural circuits involved in reading, and it appears that this cognitive ability relies not only on neural circuits related to language processing [2,3] but also those related to visual processing [3] and higher-level cognitive abilities, such as executive functions [4,5]. A fascinating orchestra of synchronized activation between the superior temporal gyrus and inferior frontal gyrus (i.e., language processing, see [2] the fusiform gyrus, cuneus and precuneus (i.e., visual processing, see ref. [3]), and the anterior cingulate cortex in particular and the cinguloopercular and fronto-parietal cognitive control networks in general [4- 6] all are needed for fluent reading. Given this involvement of multiple neural circuits and cognitive abilities, it is not surprising that reading difficulties may result from a variety of impairments or an altered activation in any of the aforementioned neural circuits. Alternatively, reading difficulties can result from a lack of synchronization between the activation of these neural circuits (i.e., altered functional connectivity). Children with dyslexia [3] attention deficit hyperactivity disorder (ADHD) [7], psychiatric disorders [8] epilepsy [9] autism [10], or mental retardation [11] all suffer from reading difficulties. However, these types of reading challenges are only the tip of the iceberg, as this is what a teacher notices in the classroom. Neuroimaging data provide us with insight into the underlying causes and pathway “flosses” (the bottom of the iceberg) that are the basis for these reading challenges. Children with dyslexia show an under activation of the fusiform gyrus compared to typical readers during reading [3], but also have decreased functional connectivity between visual- and executive functionsrelated regions (fusiform gyrus and anterior cingulate cortex) during reading [12] and the cingulo-opercular cognitive-control network (related to executive functions), even during rest [13]. Conversely, children with both ADHD and dyslexia, who showed much more severe reading difficulties than those with dyslexia alone, demonstrated greater activation in neural circuits related to executive functions (i.e., dorsolateral prefrontal cortex) compared to children with dyslexia during word reading (unpublished data). In the field of psychiatry, children with mood disorders demonstrated more severe reading and phonological-processing difficulties compared to those with behavioral disorders, as well as decreased white-matter diffusivity (fractional anisotropy) in white-matter tracks related to language processing (left arcuate fasciculus, which crosses the frontal and tempo-parietal language and reading regions) [14,15]. Neurologically, a case study of an epilepsy patient revealed reading difficulties that were manifested by right lateralized activation in the language-related right superior temporal lobe compared to a child with epilepsy with intact reading abilities and left lateralized activation in this region [16]. Highfunctioning children with autism and hyperlexia (i.e., an extraordinary ability to read words) showed greater activation of neural circuits related to visual processing (i.e., the fusiform gyrus) [17]. As of yet, there is no evidence of neural circuits supporting impaired reading in children with autism who have reading difficulties or for children with mental retardation. The main challenge of identifying the specific brain regions in many other neurological disorders that affect reading is in the inter-subjects variability. In Epilepsy, for example, reading difficulties can result from seizures in different brain regions related to language, visual processing or different cognitive abilities related to reading. Therefore, a functional / structural connectivity approach, which relates to associations between brain regions, related to these abilities would be more appropriate when characterizing the neural changes related to reading in these populations.
Determining the exact altered neural circuits related to reading difficulties is important and should be a part of the medical model of providing the most appropriate treatment for each disorder. If a child suffers from reading difficulty due to language-processing difficulties, then the appropriate intervention should focus mainly on this domain. However, for a child who suffers mainly from difficulties in executive functions, the treatment should focus on different domains. Neuroimaging data has the advantage not only to identify the neural circuits involved in underlying causes of reading impairment, but also can be used to evaluate the effectiveness of intervention programs, precisely and accurately. Another advantage of using nonscientific tools in the educational field of reading remediation is the preventative potential of its use. Recently, home literacy environment has been identified as having an impact on the developing brain: a greater home literacy environment was positively associated with activation in neural circuits related to semantic processing (i.e., the temporal-occipitalparietal junction) in 3-5 year-old children listening to stories in the MRI [18]. More research is needed to pinpoint at the neural circuits related to the inability to read due to environmental factors, such that we will be able to prevent the occurrence of illiteracy. Reading difficulties due to the hereditability of genes associated with dyslexia may also be predicted before the reading problems actually occur (i.e., in preschool). Neuroimaging data has shown that children with reading difficulties whose parents suffer from reading difficulties demonstrate much more diffused activation in neural circuits related to language (superior temporal gyrus), visual processing (fusiform gyrus), and executive functions (anterior cingulate cortex) compared to children with reading difficulties whose parents do not have reading difficulties [19]. Such genetic data could serve as a screen for the future existence of reading difficulties, which would provide reason for early treatment for children at-risk to develop reading difficulties due to environmental or genetic factors.
Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 7860
  • [From(publication date):
    December-2015 - Jul 22, 2017]
  • Breakdown by view type
  • HTML page views : 7797
  • PDF downloads :63

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version