alexa Has Aerobic Exercise Anti-inflammatory Effect for Asthma? | Open Access Journals
ISSN: 2165-7025
Journal of Novel Physiotherapies
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Has Aerobic Exercise Anti-inflammatory Effect for Asthma?

Rodolfo de Paula Vieira*
Post Graduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, São Paulo, SP, Brazil
Corresponding Author : Rodolfo de Paula Vieira
Post Graduate Program in Biophotonics Applied to Health Sciences
Nove de Julho University
São Paulo, SP, Brazil
Tel: 55-12-3626-5609
Received February 11, 2012; Accepted February 11, 2012; Published February 13, 2012
Citation: Vieira RP (2012) Has Aerobic Exercise Anti-inflammatory Effects for Asthma? J Nov Physiother 2:e108. doi: 10.4172/2165-7025.1000e108
Copyright: © 2012 Vieira RP. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Novel Physiotherapies

One of the first studies available in the literature that can be considered as an embrionary concept of pulmonary rehabilitation (PR) was performed by Livingstone and Gillespie in 1935 [1]. In this study, the authors applied respiratory exercises to asthmatic patients, aiming to increase the chest mobility [1]. However, until the middle of 20’s century the concept of PR did not exist and the treatment was exclusively pharmacological [2].
The concept of pulmonary rehabilitation including the practice of aerobic exercise training began to emerge from the 50’s, but until few years ago, the practice of exercises by asthmatics individuals was considered as irresponsibility and strongly discouraged, because asthmatics could present bronchospasm induced by exercise (BIE) [3].
On the other hand, actually, asthmatic patients are strongly encouraged to be involved in pulmonary rehabilitation programs, according to the statements of American Association of Cardiovascular & Pulmonary Rehabilitation [4,5]. This gradual change of concept represent a big advance against old paradigms, and is based in a growing number of clinical and experimental studies showing that the regular practice of aerobic exercises at appropriate volume and intensity results in several physical and psychological beneficial effects to asthmatic patients [5-15].
Compelling evidences point out to a role of aerobic exercise training in asthma physiopathology and disease control. Asthmatic patients submitted to appropriate rehabilitation program including low to moderate intensity aerobic exercise present an improvement in lung function (e.g. increase in ventilatory capacity) and asthmarelated symptoms “asthma-control” (e.g. dyspnea, exercise-induced bronchospasm or peak expiratory flow variability) [5-15]. In addition a decrease of daily use of inhaled steroids has been reported, thus suggesting an anti-inflammatory effect of exercise on asthmatic lungs [5-15]. This hypothesis was further supported by the recent findings from Gonçalves et al. and Mendes et al., demonstrating that aerobic exercise decreased the levels of exhaled nitric oxide, an established pro-inflammatory mediator in asthma, and also the number of eosinophils in induced sputum in moderate/severe persistent asthmatic patients [13,14].
In this direction, since 2004 a growing number of experimental studies using mouse models of chronic allergic airway inflammation have demonstrated that low and moderate intensity aerobic exercise performed either before, during or after the allergen sensitization results in decreased eosinophilic inflammation, Th2 cytokines production, airway remodeling and hyperresponsiveness [16-24]. Shortly, these studies have demonstrated that these beneficial effects can be attributed to decreased activation of leukocytes and bronchial epithelial cells as a result of increased activation of glucocorticoids receptors, T-regulatory cells resulting in increased synthesis of anti-inflammatory cytokine IL-10, and decreased activation of transcriptional factor NF-kB [16-24]. In addition, these studies also demonstrated that aerobic exercise present a direct inhibitory effect on the pulmonary oxidants production as well as on the synthesis of mediators involved in the airway remodeling process [19,24]. However, the precise cellular and molecular mechanisms of beneficial effects of aerobic exercise for asthma deserve further investigations.
More recently, an excellent study from Mendes et al. demonstrated for the first time that 12 weeks of moderate intensity aerobic exercise in moderate and severe asthmatic patients resulted in decreased number of eosinophils in induced sputum, proving the concept that aerobic exercise presents anti-inflammatory effects for asthma [14].
Therefore, we conclude that aerobic exercise present antiinflammatory effects for asthma and we could affirm that a new exciting research field is now open and claiming for more investigation regarding the effects of aerobic exercise on the asthma.
Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 3840
  • [From(publication date):
    March-2012 - Jun 27, 2017]
  • Breakdown by view type
  • HTML page views : 88
  • PDF downloads :3752

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version